Price: 556 €
Turnaround time: 20 working days (Monday to thrusday)
What are free radicals?
They are molecules highly reactive and harmful to the body in high concentrations.
Most of them come from the oxygen we breathe, and are called oxygen free radicals, causing oxidative damage.
Others come from the nitric oxide, a gas that is produced in excess in inflammatory processes; it reacts with some oxygen radicals, and leads to nitrogen radicals. These radicals as toxic as oxygen, and destroy cells.
Free radicals damage the lipids, the proteins, and the nucleic acids of the cell, leading to its destruction. Excessive generation is sometime cause and other times consequence of many diseases and are involved in the disease process.
What is oxidative stress?
When an excess of free radicals occurs, the body's antioxidant systems are launched to counter them; this is known as oxidative balance.
Oxidative stress is the excess free of radicals, because of:
- Saturation of antioxidant systems, which are no longer able to remove them.
The opposite situation is oxidative rest: if the antioxidant is too high (because the patient receives too much antioxidant) free radical levels are reduced below the equilibrium state.
Both stress and oxidative rest are pathological situations to be controlled: the first one, because of the oxidative damage that affects health and the second one, because the body does not have those molecules available to activate other defense systems, if necessary.
Why oxidative stress occurs with inflammation?
The immune system triggers an inflammatory process to defend itself against any invading microorganism. But when the production of free radicals increases, it activates innate immunity, turning into an acute inflammatory process which can become chronic while said radicals remain at high levels. During the inflammatory process, the production of nitric oxide and other proinflammatory factors are triggered, turning on the elevated production of nitrogen radicals. Therefore, oxidative stress is a major cause of inflammation and generation of radicals maintain, a chronic damage in the body.
Why is it important to measure mitochondrial function?
Mitochondria is the power plant for cells; where the energy that the cell need to produce all its functions, including antioxidant defense and repair mechanisms of the damage caused by free radicals, among others, is produced. Thus, the mitochondria consumes more than 95% of the oxygen we breathe, which also makes it the largest center of production of free radicals in cells. If such radicals are not controlled, the mitochondria is damaged and loses its ability to provide energy to the cell, causing cell death.
What is the purpose of this test?
Given the close relationship between free radicals, inflammation and mitochondrial damage, is needed to analyze these three systems as a group, to find a balance of antioxidant systems.
This test determines how the endogenous antioxidant system works, if there is any trouble in any of the intermediate steps, both antioxidants and reducers, as well as the degree of oxidative and inflammatory damage.
As an example, if after the analytical test the molecule that causes an oxidation state is found, there is no need to give other antioxidants, which could have deleterious effects.
- Circadian rhythm disorders.
- Assessment and anti-aging treatment.
- States of fatigue, apathy, concentration deficits, memory, etc.
- Fibromyalgia, chronic fatigue.
- Neurodegenerative diseases (Parkinson's, Alzheimer's) and epilepsy.
- Muscular dystrophies.
- Metabolic syndrome and diabetes mellitus.
- Endothelial dysfunction, hypertension.
Oxidative imbalance treatment
The results report of this test gives a detailed and comprehensive evaluation of the oxidative state, damage to macromolecules, inflammatory activation and mitochondrial dysfunction, as well as the status of endogenous antioxidant defense systems. Thereby, a vision of the redox state of the patient allows a much more specific therapy to restore redox balance is obtained.